366.
Kenneth McIntosh, Stanley Perlman, etc.,
A Proposal to Refer to Four Coronaviruses of Limited Human Virulence “Common Cold Coronaviruses”, 2022.09.02,
https://academic.oup.com/jid/article/226/12/2047/6686575 .
We propose the term “common cold coronaviruses”, or ccCoV, to describe the four human coronaviruses commonly associated with upper respiratory tract disease - coronaviruses 229E, OC43, NL63, and HKU1. This will differentiate these previously described coronaviruses from those causing more severe disease in humans – including the viruses severe acute respiraotry syndrome coronavirus (SARS-CoV), the Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2.
365.
Animesh Ray, Adarsh Aayilliath K, etc.,
Burden of Serious Fungal Infections in India, 2022.12.26,
https://academic.oup.com/ofid/article/9/12/ofac603/6960896?searchresult=1 .
Fungal disease is frequent in India, but its incidence and prevalence are unclear. A systematic review of the literature on the PubMed, Embase, and Web of Science databases was conducted using appropriate search strings. India's fungal burden is high and underappreciated in clinical practice.
364.
Wenli Cheng, Min Li, etc.,
Epidemiological characteristics of community-acquired pneumonia and effects from the COVID-19 pandemic in Shenzhen of China, 2022.12.29,
https://academic.oup.com/tropej/article/69/1/fmac111/6917080?searchresult=1 .
This study aimed to observe the impact of the coronavirus disease 2019 (COVID-19) pandemic on the incidence of non-COVID-19 community-acquired pneumonia (CAP) in Shenzhen of China, offering new ideas for evaluating the effects of non-pharmaceutical interventions. Non-pharmaceutical interventions from COVID-19 have led to a decrease in the number of CAP inpatients, especially for children, with a specific seasonal prevalence in spring and winter, when the prevention interventions should be strengthened further for adults during the pandemic.
363.
Lucy S Witt, Jessica R Howard-Anderson, etc.,
The impact of COVID-19 on multidrug-resistant organisms causing healthcare-associated infections: a narrative review, 2022.12.29,
https://academic.oup.com/jacamr/article/5/1/dlac130/6964822?searchresult=1 .
Coronavirus disease 2019 (COVID-19) changed healthcare across the world. With this change came an increase in healthcare-associated infections (HAIs) and a concerning concurrent proliferation of MDR organisms (MDROs). In this narrative review, we describe the impact of COVID-19 on HAIs and MDROs, describe potential causes of these changes, and discuss future directions to combat the observed rise in rates of HAIs and MDRO infections.
362.
Hsiang-Yeh Chen, Johnny Kuang-Wu Lee, etc.,
A global spatial analysis of factors associated with case and mortality rates for coronavirus disease 2019 during the first year of the pandemic, 2022.12.29,
https://academic.oup.com/trstmh/advance-article/doi/10.1093/trstmh/trac121/6965062?searchresult=1 .
A increasing number of studies have revealed associations between country-level determinants and coronavirus disease 2019 (COVID-19) outcomes. Obesity was significantly and positively associated with COVID-19 case and mortality rates in both the main and sensitivity analyses. With the increasing global prevalence of obesity, the relationship between obesity and COVID-19 disease at the country level must be clarified and continually monitored.
361.
M Moreno Martínez, M Feijoo-Cid, etc.,
Psychosocial risk in healthcare workers after one year of COVID-19, 2022.12.30,
https://academic.oup.com/occmed/advance-article/doi/10.1093/occmed/kqac121/6965872?searchresult=1 .
The COVID-19 pandemic overwhelmed the capacity of the healthcare system, affecting the volume of demands and the care tasks of healthcare workers. Exposure to psychosocial risks was already high during the first wave and a significant decline in working conditions was observed. The prolongation of the pandemic exacerbated these results and seems to have multiplied the pre-existing inequalities between the axes of segregation in the labour market.
360.
Henry King, Bethany Williams, etc.,
How, for whom, and in what contexts will artificial intelligence be adopted in pathology? A realist interview study, 2022.12.24,
https://academic.oup.com/jamia/advance-article/doi/10.1093/jamia/ocac254/6960637?searchresult=1 .
It must not be assumed that AI tools that provide benefit in one subspecialty will provide benefit in others. Pathologists should be involved in the decision to introduce AI, with opportunity to assess strengths and weaknesses. Further research is needed concerning the evidence required to satisfy pathologists regarding the benefits of AI.
359.
Ben Saunders,
How Mandatory Can We Make Vaccination?, 2022.12.21,
https://academic.oup.com/phe/advance-article/doi/10.1093/phe/phac026/6955798?searchresult=1 .
The novel coronavirus pandemic has refocused attention on the issue of mandatory vaccination. Some have suggested that vaccines ought to be mandatory, while others propose more moderate alternatives, such as incentives. This piece surveys a range of possible interventions, ranging from mandates through to education.
358.
Nergis Imprachim, Yuliana Yosaatmadja, etc.,
Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development, 2022.12.22,
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1207/6956356?searchresult=1 .
NSP14 is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. We perform an X-ray fragment screen on NSP14, revealing 72 hits bound to sites of inhibition in the ExoN and MTase domains. These fragments serve as excellent starting point tools for structure guided development of NSP14 inhibitors that may be used to treat COVID-19 and potentially other future viral threats.
357.
Michael A Casasanta, G M Jonaid, etc.,
Structural Insights of the SARS-CoV-2 Nucleocapsid Protein: Implications for the Inner-workings of Rapid Antigen Tests, 2022.12.22,
https://academic.oup.com/mam/advance-article/doi/10.1093/micmic/ozac036/6957293?searchresult=1 .
Complementary modeling results suggested that N protein structures from known VOC are nearly 100% conserved at specific antibody-binding sites. These results suggest that rapid tests that target the nucleocapsid C-terminal domain should have similar accuracy across all VOCs. Our combined structural modeling workflow may guide the design of immune therapies to counter viral processes as we plan for future variants and pandemics.
Chinese Society of International Law, in association with Chinese Institute of International Law at China Foreign Affairs University, and National Center for Foreign-related Rule of Law Research at China Foreign Affairs University
Contact: secretary@bigghgg.cn