33.
Gharpure R, Hunter CM, Schnall AH, et al. ,
Knowledge and Practices Regarding Safe Household Cleaning and Disinfection for COVID-19 Prevention — United States, May 2020, 2020.06.05,
http://dx.doi.org/10.15585/mmwr.mm6923e2 .
CDC conducted an Internet panel survey which identified gaps in knowledge about safe preparation, use, and storage of cleaners and disinfectants. Approximately one third of survey respondents engaged in nonrecommended high-risk practices with the intent of preventing SARS-CoV-2 transmission, including using bleach on food products, applying household cleaning and disinfectant products to skin, and inhaling or ingesting cleaners and disinfectants.
32.
Georg Wolff, Ronald W. A. L. Limpens, Jessika C. Zevenhoven-Dobbe, Ulrike Laugks, Shawn Zheng,
A molecular pore spans the double membrane of the coronavirus replication organelle, 2020.08.06,
https://science.sciencemag.org/content/early/2020/08/05/science.abd3629 .
The study found a hexameric assembly of a large viral transmembrane protein which formed the core of the crown-shaped complex. This coronavirus-specific structure likely plays a critical role in coronavirus replication and thus constitutes a potential drug target.
31.
University Of Alabama At Birmingham,
Is the COVID-19 virus pathogenic because it depletes specific host microRNAs? 2020.08.14,
https://www.eurekalert.org/pub_releases/2020-08/uoaa-itc081420.php .
UAB and Polish researchers propose that the COVID-19 virus acts as a microRNA "sponge" to deplete miRNA levels in ways that aid viral replication and stymie the host immune response.
30.
Prabhu S. Arunachalam, Florian Wimmers, Chris Ka Pun Mok, Ranawaka A. P. M. Perera,
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans, 2020.08.11,
https://science.sciencemag.org/content/early/2020/08/10/science.abc6261 .
This article analyes immune responses in 76 COVID-19 patients and 69 healthy individuals and the results highlight molecules such as EN-RAGE or TNFSF14, and their receptors, which could represent attractive therapeutic target against COVID-19.
29.
Pedro M Folegatti, Katie J Ewer, Parvinder K Aley, Brian Angus, Prof Stephan Becker, Sandra Belij-Rammerstorfer, et al.,
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial, 2020.07.20,
https://doi.org/10.1016/S0140-6736(20)31604-4 .
ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme.
28.
Feng-Cai Zhu, Xu-Hua Guan, Yu-Hua Li, Jian-Ying Huang, Tao Jiang, Li-Hua Hou, et al.,
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial, 2020.07.20,
https://doi.org/10.1016/S0140-6736(20)31605-6 .
This study shows that the Ad5-vectored COVID-19 vaccine at 5 × 1010 viral particles is safe, and induced significant immune responses in the majority of recipients after a single immunisation.
27.
Christine M Salvatore, Jin-Young Han, Karen P Acker, Priyanka Tiwari, Jenny Jin, Michael Brandler, et al.,
Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study, 2020.07.23,
https://doi.org/10.1016/S2352-4642(20)30235-2 .
this report suggests that perinatal transmission of COVID-19 is unlikely to occur if correct hygiene precautions are undertaken, and that allowing neonates to room in with their mothers and direct breastfeeding are safe procedures when paired with effective parental education of infant protective strategies.
26.
Long H Nguyen, David A Drew, Mark S Graham, Amit D Joshi, Chuan-Guo Guo, Wenjie Ma, et al. ,
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study, 2020.07.31,
https://doi.org/10.1016/S2468-2667(20)30164-X .
In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers. Health-care systems should ensure adequate availability of PPE and develop additional strategies to protect health-care workers from COVID-19, particularly those from Black, Asian, and minority ethnic backgrounds. Additional follow-up of these observational findings is needed.
25.
Ying Zhou, Renzhe Xu, Dongsheng Hu, Yang Yue, Qingquan Li, Jizhe Xia,
Effects of human mobility restrictions on the spread of COVID-19 in Shenzhen, China: a modelling study using mobile phone data, 2020.08.01,
https://doi.org/10.1016/S2589-7500(20)30165-5 .
this study shows the effects of various types and magnitudes of mobility restrictions on controlling COVID-19 outbreaks at the city level in Shenzhen, China.
Beijing Interest Group on Global Health and Global Governance
Contact: secretary@bigghgg.cn