Michael A Casasanta, G M Jonaid, etc.,
Structural Insights of the SARS-CoV-2 Nucleocapsid Protein: Implications for the Inner-workings of Rapid Antigen Tests, 2022.12.22,
Complementary modeling results suggested that N protein structures from known VOC are nearly 100% conserved at specific antibody-binding sites. These results suggest that rapid tests that target the nucleocapsid C-terminal domain should have similar accuracy across all VOCs. Our combined structural modeling workflow may guide the design of immune therapies to counter viral processes as we plan for future variants and pandemics.
Frederic Reicherz, Rui Yang Xu, etc.,
Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic, 2022.05.07,
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure. Waning immunity may explain the interseasonal resurgence of RSV cases observed in BC and other countries.
Alexandre Afonso, Fabio Votta,
Electoral and religious correlates of COVID-19 vaccination rates in Dutch municipalities, 2022.08.23,
Vaccination campaigns amid the coronavirus disease 2019 (COVID-19) pandemic have been extensively politicized in a number of countries. Controlling for a number of demographic, social and economic factors, we find a negative statistical relationship between the aggregate vote share of the populist-right wing Forum for Democracy and the vaccination rate against COVID-19 across Dutch municipalities. We also find a negative relationship between the proportion of individuals with reformed Protestant and Muslim religious beliefs.
Maj Britt Dahl Nielsen, Ola Ekholm, etc.,
Mental wellbeing among Danish employees during the COVID-19 pandemic: results from a longitudinal study on the role of industry and working environment, 2022.10.13,
Previous studies have primarily focused on the mental health and wellbeing of healthcare workers and are mostly based on cross-sectional data from non-representative samples. The aim of this study was to investigate mental wellbeing trajectories among employees from different industries, and to longitudinally identify factors that affect mental wellbeing during the COVID-19 pandemic, including job insecurity, fear of COVID-19, working from home or being discharged with wage compensation and management quality. We found that mental wellbeing declined among employees in all industries with no difference between industries.
Daniele Mipatrini, Chiara Montaldo, etc.,
‘Disease X’—time to act now and prepare for the next pandemic threat, 2022.10.17,
It is now the time to leverage the recent experience of the COVID-19 pandemic, to plan the preparedness for the future, to update the global governance and legislation and to produce international guidelines for preparedness to respond to the next Disease X.
Kyla Tozer, Calvin P Sjaarda, etc.,
Comparison of SARS-CoV-2 Viral Loads in the Nasal Mucosa of Patients Infected With BA.1, BA.2, or BA.5 Omicron Lineages, 2022.10.22,
Lower viral loads were observed in the upper respiratory tract of patients infected with BA.1, whereas patients infected with BA.2 and BA.5 had comparable viral loads to those seen with Alpha or Delta. This suggests that viral loads are likely not responsible for the increased transmission of the Omicron lineages.
Simiso Sokhela, Bronwyn Bosch, etc.,
Comparing Prospective Incident Severe Acute Respiratory Syndrome Coronavirus 2 Infection Rates During Successive Waves of Delta and Omicron in Johannesburg, South Africa, 2022.12.16,
In high-risk individuals in Johannesburg, during the Delta coronavirus disease 2019 wave, 22% (125/561) were positive, with 33% symptomatic (2 hospitalizations; 1 death). During Omicron, 56% (232/411) were infected, with 24% symptomatic (no hospitalizations or deaths). The remarkable speed of infection of Omicron over Delta poses challenges to conventional severe acute respiratory syndrome coronavirus 2 control measures.
Haruka Maeda, Nobuo Saito, etc.,
Effectiveness of Messenger RNA Coronavirus Disease 2019 Vaccines Against Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Delta Variant Epidemic in Japan: Vaccine Effectiveness Real-time Surveillance for SARS-CoV-2 (VERSUS), 2022.04.19,
Although high vaccine effectiveness of mRNA COVID-19 vaccines has been reported in studies in several countries, data are limited from Asian countries, especially against the Delta (B.1.617.2) variant. We conducted a multicenter test-negative case-control study in patients aged ≥16 years visiting hospitals or clinics with signs or symptoms consistent with COVID-19 from 1 July to 30 September 2021, and found mRNA COVID-19 vaccines had high effectiveness against symptomatic SARS-CoV-2 infections in Japan during July–September 2021, when the Delta variant was dominant nationwide.
Amihai Rottenstreich, Olesya Vorontsov, etc.,
Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination, 2022.05.24,
We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.
Char Leung, Li Su, etc.,
Better healthcare can reduce the risk of COVID-19 in-hospital post-partum maternal death: evidence from Brazil, 2022.08.10,
COVID-19 in post-partum women is commonly overlooked. Post-partum women had almost twice the odds of COVID-19 in-hospital mortality compared with pregnant patients. Part of the mortality risk is preventable through quality healthcare such as the presence of an obstetric centre in the hospital, non-profit private healthcare and hospitals in urban areas.
Beijing Interest Group on Global Health and Global Governance